NMO-Ab and MOG-Ab could be potential biomarkers to determine visual prognosis in patients with ON. In the other 3 groups (NMO-Ab/MOG-Ab, NMO-Ab/MOG-Ab, and NMO-Ab/MOG-Ab), visual acuity did not change significantly (P = 0.53, 0.42, and 0.45, respectively). Antibodies against myelin oligodendrocyte glycoprotein (MOG) have been identified in a subgroup of pediatric patients with inflammatory demyelinating. In the NMO-Ab/MOG-Ab group, visual acuity improved significantly (P < 0.0001). Three (50%) of 6 eyes of patients seropositive for both antibodies did not respond to corticosteroid pulse therapy and plasmapheresis, and visual acuity remained unchanged. Ten (43%) of 23 patients were seronegative for both antibodies. Six (26%) of 23 patients were seropositive for both NMO-Ab and MOG-Ab. MOG-Ab seropositivity was defined by comparing with MOG-Ab level obtained from 8 healthy normal subjects.Įleven (47%) of 23 ON patients were NMO-Ab seropositive, while 8 (34%) of the 23 patients were MOG-Ab seropositive. At presentation, serum NMO-Ab was measured by immunofluorescence using HEK 293 cells transfected with AQP4-GFP, and anti-MOG1-125 antibody was measured by enzyme-linked immunosorbent assay. Myelin Oligodendrocyte Glycoprotein (MOG) is a glycoprotein which is part of normal myelin and is found on the surface of the myelin sheath of nerve cells. Thirty-three eyes of 23 patients with ON were studied. C’est une maladie démyélinisante touchant la moelle épinière et les nerfs optiques. La neuromyélite optique (NMO) ou maladie de Devic est une maladie auto-immune rare puisqu’elle représente moins de 1 des maladies inflammatoires du système nerveux central (SNC). T2-weighted central longitudinally extensive cervical lesion. NOUVELLE ANALYSE: LES ANTICORPS ANTI-NMO. Examples of longitudinally extensive spinal cord lesions detected by MRI in AQP4- seropositive NMOSD patients. We investigated the relationship between NMO antibody (NMO-Ab) and anti-MOG antibody (MOG-Ab) and potential in patients with ON for recovery of vision. The correct differentiation of NMOSD and anti-MOG syndromes from MS is important to provide patients with the most appropriate treatment. MOG antigen is currently considered as a cause of optic neuritis (ON) associated with MS because immunization with MOG antigen derived from oligodendrocytes induces murine ON with myelitis. Myelin oligodendrocyte glycoprotein (MOG) is well known as the causative protein of multiple sclerosis (MS). PMID 8530032.Damage to astrocytes by anti-aquaporin-4 antibody (AQP4-Ab), also known as NMO antibody, has been implicated as the cause of neuromyelitis optica. “The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization”. “Aquaporins and Their Regulation after Spinal Cord Injury”. Halsey, Andrea Conner, Alex Bill, Roslyn Logan, Ann Ahmed, Zubair (). Interpretation of the results must be made in the context of clinical signs and symptoms. Anti-MOG antibodies are NOT a reliable biomarker in adult onset multiple sclerosis. There is consensus that anti-MOG antibodies are important in both pediatric and adult demyelination, and the clinical association of MOG autoantibody-associated demyelination has been refined to include acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis, and transverse myelitis. MOG is also considered to serve a function as an adhesion molecule to provide structural integrity to the myelin sheath. MOG (Myelin oligodendrocyte glycoprotein) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system. Autoantibodies against aquaporin-4 is prevalent in neuromyelitis optica (NMO). AQP4 facilitates water movement near cerebrospinal fluid and vasculature. Aquaporin-4 is one of the exclusive aquaporin proteins found in the central nervous system – particularly being the most prevalent aquaporin protein in the cerebellum and spinal cord grey matter. Aquaporin-4, also known as AQP4 or NMO-IgG, is a water channel membrane protein that conducts water through the cell membrane. Mitogen’s Neuromyelitis Spectrum assay is an autoimmune diagnostic test that detects autoantibodies to Aquaporin 4 & Anti-Myelin Oligodendrocyte Glycoproteins (MOG). Initially, the presence of anti-MOG was thought to be associated with fewer relapses and better outcomes than those with AQP-4 positive NMOSD,5,8 but.
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